Zentralinstitut für Klinische Chemie und Laboratoriumsmedizin mit Laborpraxis

Publikationen

Bücherregal

2021

Reichert F, Enninger A, Plecko T, Zoller WG, Paul G
Pooled SARS-CoV-2 antigen tests in asymptomatic children and their caregivers: Screening for SARS-CoV-2 in a pediatric emergency department
Am J Infect Control (2021) 49(1)

Paul G, Plecko T, Sethi S, Schilling T, Wienand O, Jürgensen JS, Menzel U
Klinische Performance eines neuen SARS-CoV-2-Antigen-Tests in der Notaufnahme eines Maximalversorgers
Epid Bull (2021) 3: 13-18

2020

Burghartz M, Sittel C, Fiz I, Taxis D, Plecko T, Kolkmeyer CA, Hagen R, Hackenberg S
Einfluss gutartiger Tumoren der Glandula parotis auf die Gesamtspeichelflussrate
Laryngo-Rhino-Otologie (2020) 99(8)

2018

Doerr Stefan, Steffen Schöntag, Shneh Sethi, Ralf Lobmann,
Kodamea Ohmeri-Seltener Erreger eines Diabet. Fußsyndroms (DFS)
Poster, Kongress der Südwestdeutschen Gesellschaft für Innere Medizin

Langlois MR, Chapman MJ, Cobbaert C, Mora S, Remaley AT , Ros E, Watts GF, Borén J, Baum H, Bruckert E, Catapano A, Descamps OS, von Eckardstein A, KamstrupPR, Kolovou G, Kronenberg F, Langsted A, Pulkki K, Rifai N, Sypniewska G, Wiklund O and Nordestgaard BG for the European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) joint Consensus Initiative.
Quantifying atherogenic lipoproteins: current and future challenges in the era of personalized medicine and very low LDL-cholesterol. A consensus statement from EAS and EFLM.
Clin Chem 2018;64:1006-1033

Jassam N, Lake J, Dabrowska M, Queralto J, Rizos D, Lichtinghagen R, Baum H, Ceriotti F, O’Mullane J, Homsak E, Charilaou C, Ohlson M, Rako I, Vitkus D, Kovac G, Verschuure P, Racek J, Chifiriuc MC and Wieringa G.
The European Federation of Clinical Chemistry and Laboratory Medicine syllabus for postgraduate education and training for Specialists in Laboratory Medicine: version 5 – 2018.
Clin Chem Lab Med 2018: doi.org/10.1515/cclm-2018-0344

Vogt N, Baum H.
Comparison of cobas m511 Bloodhound technology to Pentra Nexus routine hematology analyzer.
Poster, Jahrestagung der DGKL 2018, Mannheim

Rieger H, Schmidt P, Schaeffeler E, Abe M, Schiffhauer M, Schwab M, von Ahsen N, Zurek G, Kirchherr H, Shipkova M, Wieland E.
Validation of a high-performance liquid chromatography method for thiopurine S-methyltransferase activity in whole blood using 6-mercaptopurine as substrate.
Clin Chem Lab Med. 2018 Apr 25;56(5):803-809. doi: 10.1515/cclm-2017-0670

Luz, H.  D-Dimere
Eine Kurzübersicht. LabTOPs – Wissenswertes aus der Laboratoriumsmedizin, Klinikum Stuttgart;
24. Ausgabe Juli 2018

Plecko T, Berbalk K, Wieland E, Shipkova M
Evaluation of an Ion Trap Toxtyper Liquid Chromatography With An Ion Trap Mass Spectrometric Instrument (Toxtyper) for Drug of Abuse Screening in Oral Fluid.
Ther Drug Monit. 2018; 40(5): 642-648

2017

Stove V, Ramos PA, Wallemacq P, Vogeser M, Schuetzenmeister A, Schmiedel C, Shipkova M.
Measurement of sirolimus concentrations in human blood using an automated electrochemiluminescence immunoassay (ECLIA): a multicenter evaluation.

Clin Chem Lab Med. 2017 Dec 5.

Rieger H, Schmidt P, Schaeffeler E, Abe M, Schiffhauer M, Schwab M, von Ahsen N, Zurek G, Kirchherr H, Shipkova M, Wieland E.
Validation of a high-performance liquid chromatography method for thiopurine S-methyltransferase activity in whole blood using 6-mercaptopurine as substrate.

Clin Chem Lab Med. 2017 Dec 1.

Arns W, Huppertz A, Rath T, Ziefle S, Rump LC, Hansen A, Budde K, Lehner LJ, Shipkova M, Baeumer D, Kroeger I, Sieder C, Klein T, Schenker P.
Pharmacokinetics and Clinical Outcomes of Generic Tacrolimus (Hexal) Versus Branded Tacrolimus in De Novo Kidney Transplant Patients: A Multicenter, Randomized Trial.

Transplantation. 2017 Nov;101(11):2780-2788.

van Gelder T, Fischer L, Shihab F, Shipkova M.
Optimizing everolimus exposure when combined with calcineurin inhibitors in solid organ transplantation.

Transplant Rev (Orlando). 2017 Jul;31(3):151-157.

Shipkova M, Rapp S, Rigo-Bonnin R, Wieland E, Peter A.
Therapeutic Drug Monitoring of everolimus: comparability of concentrations determined by two immunoassays and a LC-MS/MS method.
Ther Drug Monit. 2017 Jan 24.

Ott M, Berbalk T, Plecko T, Wieland E, Shipkova M.
Detection of drugs of abuse in urine using the Bruker ToxtyperTM: Experiences in a routine clinical laboratory Setting.
Clin Mass Spectrom. 2017; 4-5: 11-18.

2016

Seger C, Shipkova M, Christians U, Billaud EM, Wang P, Holt DW, Brunet M, Kunicki P, Pawinski T, Langman LJ, Marquet P, Oellerich M, Wieland E, Wallemacq P.
Assuring the Proper Analytical Performance of Measurement Procedures for Immunosuppressive Drug Concentrations in Clinical Practice: Recommendations of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Immunosuppressive Drug Scientific Committee. Ther Drug Monit  2016;38:170-189
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Brunet M, Shipkova M, van Gelder T, Wieland E, Sommerer C, Budde K, Haufroid V, Christians U, Lopez-Hoyos M, Barten MJ, Bergan S, Picard N, Millan Lopez O, Marquet P, Hesselink DA, Noceti O, Pawinski T, Wallemacq P, Oellerich M.
Barcelona Consensus on Biomarker-Based Immunosuppressive Drugs Management in solid Organ Transplantation. Ther Drug Monit 2016;38:1-20
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Shipkova M, Hesselink DA, Holt DW , Billaud EM, van Gelder T, Kunicki P, Brunet M, Budde K, Barten MJ, De Simone P, Wieland E, Millan Lopez O, Masuda S, Seger C,  Picard N,  Oellerich M, Langman LJ, Wallemacq P, Morris RG, Thompson C,  Marquet P.
Therapeutic Drug Monitoring of everolimus: A Consensus Report. Ther Drug Monit 2016;38:143-169
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Rissling O, Bauer S, Shipkova M, Glander P, Mai M, Hambach P, Budde K.
Simultaneous determination of mycophenolate and its metabolite
mycophenolate-7-o-glucuronide with an isocratic HPLC-UV-based method in human
plasma and stability evaluation.
Scand J Clin Lab Invest. 2016 Dec;76(8):612-619. PubMed PMID: 27676419.

Abdel-Kahaar E, Giese T, Sommerer C, Rieger H, Shipkova M, Wieland E.
Analytical Validation and Cross-Validation of an NFAT-Regulated Gene Expression
Assay for Pharmacodynamic Monitoring of Therapy With Calcineurin Inhibitors.
Ther
Drug Monit. 2016 Dec;38(6):711-716. PubMed PMID: 27661400.

Abdel-Kahaar E, Kabakchiev M, Hartmann B, Wieland E, Shipkova M.
Performance of a phosphoflow assay to determine phosphorylation of S6 ribosomal protein as a
pharmacodynamic read out for mTOR inhibition.
Clin Biochem. 2016 Oct;49(15):1181-1187. doi: 10.1016/j.clinbiochem.2016.06.012. PubMed PMID: 27372285.

Metzker M, Shipkova M, von Ahsen N, Andag R, Abe M, Canzler O, Klett C, Leicht S, Olbricht C, Wieland E.
Analytical evaluation of a real-time PCR-based DNA demethylation assay to assess the frequency of naturally occurring regulatory T cells in peripheral blood. Clin Biochem. 2016 Oct;49(15):1173-1180. doi: 10.1016/j.clinbiochem.2016.05.019. PubMed PMID: 27220060.

Shipkova M, Svinarov D.
LC-MS/MS as a tool for TDM services: Where are we? Clin Biochem. 2016 Sep;49(13-14):1009-23. doi: 10.1016/j.clinbiochem.2016.05.001. PubMed PMID: 27163969.

2015

Sethi S, Thormann U, Sommer U, Stötzel S, Mohamed W, Schnettler R, Domann E, Chakraborty T, Alt V.
Impact of prophylactic CpG Oligodeoxynucleotide application on implant-associated
Staphylococcus aureus bone infection.

Bone. 2015 Sep;78:194-202. doi: 10.1016/j.bone.2015.04.030. Epub 2015 May 8

Wieland E, Shipkova M.
T cell Surface Antigens and sCD30 as Biomarkers of the Risk of Rejection in Solid Organ Transplantation. Ther Drug Monit. 2015 Oct 22. [Epub ahead of print]

Shipkova M, López OM, Picard N, Noceti O, Sommerer C, Christians U, Wieland E.
Analytical aspects of the implementation of biomarkers in clinical transplantation. Ther Drug Monit. 2015 Jul 30.

Valbuena H, Shipkova M, Kliesch SM, Müller S, Wieland E.
Comparing the effect of isotopically labeled or structural analog internal standards on the performance of a LC-MS/MS method to determine ciclosporin A, everolimus, sirolimus and tacrolimus in whole blood. Clin Chem Lab Med. 2015 Aug 19 [Epub ahead of print]

Wieland E, Shipkova M.
Lymphocyte surface molecules as immune activation biomarkers. Clin Biochem. 2015 Aug 4 [Epub ahead of print]

Shipkova M.
Biomarker Monitoring in Immunosuppressant Therapy: An Overview. In Personalized Immunosuppression in Transplantation, Oellerich M und Dasgupta A, Hrsg. Elsevier, Amsterdam 2015, 125-152.

Wieland E.
Markers of Lymphocyte Activation and Proliferation. In Personalized Immunosuppression in Transplantation, Oellerich M und Dasgupta A, Hrsg. Elsevier, Amsterdam 2015, 227-257.

Beck J, Oellerich M, Schulz U, Schauerte V, Reinhard L, Fuchs U, Knabbe C, Zittermann A, Olbricht C, Gummert JF, Shipkova M, Birschmann I, Wieland E, Schütz E.
Donor-Derived Cell-Free DNA Is a Novel Universal Biomarker for Allograft Rejection in solid Organ Transplantation. Transplant Proc. 2015 Oct;47(8):2400-3

Engelmayer J, Wieland E, Brandhorst G, Oellerich M.
Comparability and imprecision of 8 frequently used commercially available immunoassays for therapeutic drug monitoring. Ther Drug Monit. 2014 Aug;36(4):433-41.

2014

Wieland E, Shipkova M.
Biomarker im Blut zur Individualisierung der immunsuppressiven Therapie nach Transplantation solider Organe. J Lab Med. 2014;38(6):333-343.

Shipkova M, Petrova DT, Rosler AE, Orth M, Engelmayer J, Wieland E, Brandhorst G, Oellerich M.
Comparability and imprecision of 8 frequently used commercially available immunoassays for therapeutic drug monitoring. Ther Drug Monit. 2014 Aug;36(4):433-41.

Shipkova M, Vogeser M, Ramos PA, Verstraete AG, Orth M, Schneider C, Wallemacq P.
Multi-center analytical evaluation of a novel automated tacrolimus immunoassay. Clin Biochem. 2014 Aug;47(12):1069-77.

Vogeser M, Shipkova M, Rigo-Bonnin R, Wallemacq P, Orth M, Widmann M, Verstraete AG.
Multicenter analytical evaluation of the automated electrochemiluminescence immunoassay for cyclosporine. Ther Drug Monit. 2014 Oct;36(5):640-50.

2013

Shipkova M, Petrova D, Rosler AE, Orth M, Engelmayer E, Wieland E, Brandhorst G, Oellerich M: Comparability and imprecision of eight frequently used commercially available immunoassays for therapeutic drug monitoring. Ther Drug Monit 2014, im Druck

Leicht S, Shipkova M, Klett C, Gert H, Altrock E, Wilhelm J, Bolley R, Wollmeyer J, Ender A, Luz B, Olbricht C, Wieland E: CD26/dipeptidyl peptidase IV: a comparative study of healthy persons and kidney transplant recipients before and early after transplantation. Clin Biochem. 2013; 46(15):1383-8

Arns W, Sommerer C, Glander P, Ariatabar T, Porstner M, May C, Paulus EM, Shipkova M, Fischer W, Liefeldt L, Hackenberg R, Schemmer P, Domhan S, Zeier M, Budde K: A randomized trial of intensified vs. standard dosing for enteric-coated mycophenolate sodium in de novo kidney transplant recipients: results at 1 year. Clin Nephrol. 2013, 79(6):421-31

Kirchherr H, Shipkova M, von Ahsen N: Improved method for therapeutic drug monitoring of 6-thioguanine nucleotides and 6-methylmercaptopurine in whole-blood by LC/MSMS using isotope-labeled internal standards. Ther Drug Monit. 2013 Jun; 35(3):313-21

Hüttemann M, Shipkova M, Klett C, Hasche G, Wilhelm J, Bolley R, Olbricht C, Wieland E: Total and free plasma concentrations of the active metabolite of leflunomide in relation to therapeutic outcome in kidney transplant recipients with BK-virus nephropathy. Transplant Proc. 2013; 45(4):1611-3

Schettler V, Neumann CL, Hagenah GC, Schulz EG, Wieland E: How to optimize lipoprotein apheresis treatment – a second look. Atheroscler Suppl. 2013; 14(1):89-92

Neumann CL, Schulz EG, Hagenah GC, Platzer U, Wieland E, Schettler V: Lipoprotein apheresis – more than just cholesterol reduction? Atheroscler Suppl. 2013; 14(1):29-32

Wieland E, Klühe C, Shipkopva M: Neue Entwicklungen in der Laboranalytik für Klinische Studien zur Zulassung von Arzneimitteln – Good Clinical Laboratory Practice (GCLP). J Lab Med 2013; 37(6):351–362

Wieland, E, Plecko T. Laboratoriumsmedizin, Pschyrembel Klinisches Wörterbuch 2014. De Grutyer, Berlin/Boston 2013.

2012

Stracke S, Shipkova M, Mayer J, Keller F, Zarghom A, Yang L, Henne-Bruns D, Wieland E:
Pharmacokinetics and pharmacodynamics of mycophenolate sodium (EC-MPS) co-administered with cyclosporine in the early-phase post-kidney transplantation. Clin Transplant. 2012 Jan;26(1):57-66

Wieland E, Shipkova M, Oellerich M: Biomarkers in transplantation medicine: Guide to the next level in immunosuppressive therapy. Clin Chim Acta. 2012; 413:1309
Shipkova M, Wieland E: Surface markers of lymphocyte activation and markers of cell proliferation. Clin Chim Acta. 2012; 413:1338-49
Oellerich M, Brandhorst G, Shipkova M, Wieland E: Biomarkers: The link between therapeutic drug monitoring and pharamacodynamics of immunosuppressants, in Therapeutic Drug Monitoring. Newer Drugs and Biomarkers, hg von A. Dasgupta. Elsevier Verlag London, New York, 1. Auflage 2012, S 349-72
Schettler V, Neumann CL, Hulpke-Wette M, Hagenah GC, Schulz EG, Wieland E; German Apheresis Working Group: Current view: indications for extracorporeal lipid apheresis treatment. Clin Res Cardiol Suppl. 2012; 7:15-9
Schettler V, Neumann CL, Hagenah GC, Schulz EG, Wieland E: How to optimize lipoprotein apheresis treatment - A second look. Atheroscler Suppl. 2013; 14:89-92
Neumann CL, Schulz EG, Hagenah GC, Platzer U, Wieland E, Schettler V: Lipoprotein apheresis - More than just cholesterol reduction? Atheroscler Suppl. 2013; 14:29-32
Abe M, Klein B, Beyer von Voigt T, Klett C, Wieland E: Internally controlled panfungal real-time LightCycler PCR and subsequent sequencing for  the early diagnosis of invasive fungal infetion. Clin Chem Lab Med. 2012; 50:A231
Kirchherr H, Shipkova M, von Ahsen M: Improved method for therapeutic drug monitoring of 6-thioguanine nucleotides (6-TGN, 6-MMP) in whole blood by LCMSMS using isotope-labelled internal standards. Clin Chem Lab Med. 2012; 50:A250
Hüttemann M, Shipkova M, Klett C, Hasche G, Wilhelm J, Bolley R, Olbricht CJ, Wieland E: Total and free plasma concentration of the active metabolite of leflunomide in relation to therapeutic outcome in kidney transplant recipients (KTR) with BK-virus nephropathy (BKN). Abstract 24th International Congress of the Transplantation Society, 13.-19. Juli 2012, Berlin
Leicht S, Shipkova M, Klett C, Wilhelm J, Bolley R, Wollmeyer J, Ender A, Luz B, Olbricht C, Wieland E: CD26 expression on T cells early after kidney transplantation (KTx) as a potential biomarker to evaluate the risk of acute rejection. Abstract 24th International Congress of the Transplantation Society, 13.-19. Juli 2012, Berlin
Kabakchiev M, Häfner S, Olbricht CJ, Lobmann R, Wieland E: Indicators of inflammation and oxidized low desnity lipoproteins in kideny trasnplant recipients with and without metabolic syndrome. Abstract 24th International Congress of the Transplantation Society, 13.-19. Juli 2012, Berlin

2011

Stracke S, Shipkova M, Mayer J, Keller F, Zarghom A, Yang L, Henne-Bruns D, Wieland E:
Pharmacokinetics and pharmacodynamics of mycophenolate sodium (EC-MPS) co-administered with cyclosporine in the early-phase post-kidney transplantation. Clin Transplant. 2012 Jan;26(1):57-66

Shipkova M, Wieland E:
Peripheral biomarkers as a complementary tool to TDM for individualizing immunosuppression in transplantation medicine 3.5. Surface markers of lymphocyte activation and markers of cell proliferation. Clin Chim Acta. 2011 Nov 19. [Epub ahead of print]

Shipkova M, Franz J, Abe M, Klett C, Wieland E, Andus T:
Association between adverse effects under azathioprine therapy and inosine triphosphate pyrophosphatase activity in patients with chronic inflammatory bowel disease. Ther Drug Monit. 2011 Jun;33(3):321-8

Wieland E, Shipkova M, Martius Y, Hasche G, Klett C, Bolley R, Olbricht CJ:
Association between pharmacodynamic biomarkers and clinical events in the early phase after kidney transplantation: a single-center pilot study. Ther Drug Monit. 2011 Jun;33(3):341-9

Peter A, Shipkova M, Wieland E, Schleicher E, Müller I:
Increased cyclosporine concentrations in the absence of cyclosporine administration. Clin Chem. 2011 May;57(5):670-3

Kofler S, Wolf C, Shvets N, Sisic Z, Müller T, Behr J, Sohn HY, Vogeser M, Shipkova M, Meiser B, Steinbeck G, Reichart B, Kaczmarek I:
The proton pump inhibitor pantoprazole and its interaction with enteric-coated mycophenolate sodium in transplant recipients. J Heart Lung Transplant. 2011 May;30(5):565-71

Sommerer C, Glander P, Arns W, Ariatabar T, Kramer S, Vogel EM, Shipkova M, Fischer W, Liefeldt L, Hackenberg R, Schmidt J, Zeier M, Budde K:
Safety and efficacy of intensified versus standard dosing regimens of enteric-coated mycophenolate sodium in de novo renal transplant patients. Transplantation. 2011 Apr 15;91(7):779-85

Schettler V, Völker K, Schulz EG, Wieland E:
Impact of lipid apheresis on Egr-1, c-Jun, c-Fos, and Hsp70 gene expression in white blood cells. Ther Apher Dial. 2011 Feb;15(1):105-12

Abstracts:

Shipkova M, Petrova D, Rosler AE, Orth M, Engelmayer J, Wieland E, Brandhorst G, Oellerich M:
Comparability and imprecision of eight frequently used commercially available immunoassays for therapeutic drug monitoring. Ther Drug Monit 2011,33:501

Shipkova M, Stracke S, Mayer J, Keller F, John J, Wittau M, Henne-Bruns D, Wieland E:
Pharmacokinetics (PK) and pharmacodynamics (PD) of EC-MPS in kidney transplant recipients (KTR) co-treated with tacrolimus. Ther Drug Monit 2011,33:531

Leicht S, Shipkova M, Klett C, Gert H, Krizan E, Wilhelm J, Bolley R. Ender A, Luz B,, Olbricht C, Wieland E:
CD26/Dipeptidyl Peptidase IV: a comparative study ofhealthy persons and kidney transplant recipients, before and aftertransplantation. Ther Drug Monit 2011,33:531

Shipkova M, Franek G, Stahl K, Rapp K, Stier S, Hauser G, Wieland E:
Evaluation of a modified Syva-EMIT assay for quantification of methotrexate (MTX) in plasma on the Dimension VISTA platform. Ther Drug Monit 2011,33:549

Brandhorst G, Shipkova M, Rosler A, Orth M, Engelmayer J, Wieland E, Oellerich M:
Comparison and imprecision of eight frequently used commercially available immunoassays for therapeutic drug monitoring. Clin Chem Lab Med 2011; 49, Special Suppl, pp S1 – S874

2010

Abe M, Klett C, Wieland E, Gille S, Landt O.: Simultaneous quantification and genotyping of hepatitis C virus RNA by a two-step real-time PCR assay on the lightcycler instrument. Folia Med (Plovdiv). 2010 Jul-Sep;52(3):21-30.

Wieland E, Olbricht CJ, Süsal C, Gurragchaa P, Böhler T, Israeli M, Sommerer C, Budde K, Hartmann B, Shipkova M, Oellerich M.: Biomarkers as a tool for management of immunosuppression in transplant patients. Ther Drug Monit. 2010 Oct;32(5):560-72.

P. Glander, C. Sommerer, W. Arns, T. Ariatabar, S. Kramer, E.M. Vogel, M. Shipkova, W. Fischer, M. Zeier, K. Budde
Pharmacokinetics and Pharmacodynamics of Intensified versus Standard Dosing of Mycophenolate Sodium in Renal Transplant Patients.
Clin J Am Soc Nephrol. 2010 Feb 11; (Epub ahead of print).

D.R. Kuypers, Y.L. Meur, M. Cantarovich, M.J. Tredger, S.E. Tett, D. Cattaneo, B. Tönshoff, D.W. Holt, J. Chapman, T. Gelder
Transplantation Society (TTS) Consensus Group on TDM of MPA. Consensus report on therapeutic drug monitoring of mycophenolic acid in solid organ transplantation.
Clin J Am Soc Nephrol. 2010 Feb; 5(2): 341-58

M. Shipkova, E. Schütz, I. Besenthal, P. Fraunberger, E. Wieland
Investigation of  the crossreactivity of mycophenolic acid glucuronide metabolites and of mycophenolate mofetil in the Cedia MPA assay.
Ther Drug Monit. 2010 Feb; 32(1): 79-85.

H. Feichtiger, E. Wieland, V.W. Armstrong, M. Shipkova
The acyl glucuronide metabolite of mycophenolic acid induces tubulin polymerization in vitro.
Clin Biochem. 2010 Jan; 43(1-2): 208-13

M. Abe
Serie Zukunft der Medizin (4): Lab-on-a-chip Nanotechnologie für die In-vitro-Diagnostik.
MTA-Dialog 2010 Jan (11. Jahrgang); 30-33

M. Abe
Serie Zukunft der Medizin( 5): Thera(g)nostik.
MTA-Dialog 2010 Feb (11. Jahrgang); 102-105

2009

T. Heller, A.R. Asif, D.T. Petrova, Y. Doncheva, E. Wieland, M. Oellerich, M. Shipkova, V.W. Armstrong
Differential proteomic analysis of lymphocytes treated with mycophenolic acid reveals caspase-3 induced cleavage of Rho GDP dissociation inhibitor.
Ther Drug Monit 2009; 31(2): 211-7

D. Czock, F.M. Rasche, B. Boesler, M. Shipkova, F. Keller
Irinotecan in cancer patients with end-stage renal failure.
Ann Pharmacother 2009; 43(2): 363-9

D.T. Petrova, T. Heller, R. Hitt, E. Wieland, M. Oellerich, V.W. Armstrong, M. Shipkova
Regulation of IL2 and NUCB1 in mononuclear cells treated with acyl glucoronide on mycophenolic acid reveals effects independent of inosine monophosphate dehydrogenase inhibition.
Ther Drug Monit 2009; 31(1): 31-41

V. Schetller, E. Wieland
A case report of darbepoetin treatment in a patient with sickle cell disease and chronic renal failure undergoing regular hemodialysis procedures that induce a dose-dependent extension of blood transfusion intervals.
Ther Apher Dial 2009; 13(1): 80-2

M. Abe
Serie Molekularbiologie (4): DNA-Sequenzierung.
MTA-Dialog 2009; 1(10): 10-12

M. Abe
Serie Molekularbiologie (5): genetischer Fingerabdruck.
MTA-Dialog 2009; 2(10): 106-108

M. Abe
Serie Molekularbiologie (6): Fluoreszenz-in-situ-Hybridizierung.
MTA-Dialog 2009; 3(10): 179-181

M. Abe
Serie Molekularbiologie (7): DNA-Microarray.
MTA-Dialog 2009; 4(10): 275-277

M. Abe
Serie Molekularbiologie (8): Gentechnik in der Medizin.
MTA-Dialog 2009; 5(10): 362-365

M. Abe
Serie Molekularbiologie (9): Klonieren, Klonen und regenerative Medizin.
MTA-Dialog 2009; 6(10): 457-460

M. Abe
Serie Molekularbiologie (10): Transgene Organismen.
MTA-Dialog 2009; 7(10): 544-547

M. Abe
Serie Molekularbiologie (11): Gentherapie.
MTA-Dialog 2009; 8(10): 636-639

M. Abe
Serie Molekularbiologie (12): Personalisierte Medizin.
MTA-Dialog 2009; 9(10): 706-709

K. Rupprecht, C. Schmidt, A. Raspé, F. Schweda, M. Shipkova, W. Fischer, M. Bucher, F. Kees, L. Faerber
Bioavailability of mycophenolate mofetil and enteric-coated mycophenolate sodium is differentially affected by pantoprazole in healthy volunteers.
J Clin Pharmacol. 2009 Oct; 49(10): 1196-201

S. Atanasova, E. Wieland, C. Schlumbohm, M. Korecka, L. Shaw, N. von Ahsen, E. Fuchs, M. Oellerich, V.W. Armstrong
Prenatal dexamethasone exposure in the common marmoset monkey enhances gene expression of antioxidant enzymes in the aorta of adult offspring.
Stress. 2009; 12(3): 215-24

M. Abe
Internally Controlled Quantification and Genotyping of Hepatitis B Virus for Genotypes A to G by Melting Curve Analysis on the LightCycler.
6. DGKL-Kongress, Leipzig, Oktober 2009 (Poster/Abstract)

M. Abe
Serie Zukunft der Medizin (1): Nanotechnologie und Nanomedizin.
MTA-Dialog 2009; 10(10): 813-816

M. Abe
Zukunft der Medizin (2): Nanotechnologie und Nanomedizin: Therapie.
MTA-Dialog 2009; 11(10): 898-900

M. Abe
Zukunft der Medizin (3): Nanomedizin: molecular imaging für die In-vivo-Diagnostik.
MTA-Dialog 2009; 12(10): 1000-1003

2008

M. Abe, C. Klett, E. Wieland, S. Gille, O. Landt (2008)
Two-step realtime PCR quantification of all subtypes of human immunodeficiency virus type 1 by an in-house method using locked nucleic acid-based probes.
Folia Med (Plovdiv) 50, 5-13.

S. Atanasova, E. Wieland, C. Schlumbohm, M. Korecka, L. Shaw, N. von Ahsen, E. Fuchs, M. Oellerich, V.W. Armstrong (2008)
Prenatal dexamethasone exposure in the common marmoset monkey enhances gene expression of antioxidant enzymes in the aorta of adult offspring.
Stress 12(3), 215-24

M. Shipkova, Y. Martius, G. Hasche, C. Klett, R. Bolley, E. Wieland, C.J. Olbricht (2008)
Zusammenhang zwischen phramakokinetischen Parametern (PK) und klinischen Ereignissen unter der Therapie mit EC-MPS in der frühen Phase nach Nierentransplantation (NTx).
Nieren- und Hochdruckrankheiten 37, 529.

M. Shipkova, Y. Martius, G. Hasche, C. Klett, R. Bolley, C.J. Olbricht, E. Wieland (2008)
Zusammenhang zwischen phramakodynamischen Parametern (PK) und klinischen Ereignissen unter der Therapie mit EC-MPS in der frühen Phase nach Nierentransplantation (NTx).
Nieren- und Hochdruckrankheiten 37, 530.

E. Wieland, M. Shipkova, Y. Martius, G. Hasche, C. Klett, R. Bolley, C. Olbricht (2008)
Association between pharmacodynamic parameters and clinical events under therapy with EC-MPS in the early phase after kidney transplantation (KTx).
Ann Transplant, 13 (Suppl.1),33.

M. Abe (2008)
Real-Time-PCR, Methode zur Zeit- und Kostenreduktion in der Molekularbiologie.
MTA-Dialog, 3(9), 180-182

M. Abe (2008)
Harnsteinanalyse mittels Infrarotspektroskopie.
MTA Dialog, 7(9), 558-561

M. Abe (2008)
MRSA-Diagnostik mit Single-Locus Real-Time PCR.
MTA-Dialog 8(9), 640-643

M. Abe (2008)
Serie Molekularbiologie (1) – Definition der Molekularbiologie.
MTA Dialog, 9(9), 732-735

M. Abe (2008)
Internally controlled quantification of human Polymavirus type 1 (BK virus) DNA from plasma und urine specimes using the LightCycler.
Abstrakt und Posterpräsentation beim 5. DGKL-Kongress, Mannheim, September

M. Abe (2008)
Serie Molekularbiologie (2) Gene und Genom.
MTA-Dialog, 10(9), 839-841

M. Abe (2008)
Serie Molekularbiologie (3) Polymerase Chain Reaction (PCR).
MTA-Dialog, 11(9), 921-923

2007

Hermsen D, Apple F, Garcia-Beltran L, Jaffe A, Karon B, Lewandrowski E, Mühlbacher A, Müller R, Ordonez J, Pagani F, Panteghini M, Plecko T, Jarausch J
Results from a multicenter evaluation of the 4th generation Elecsys Troponin T assay
Clin Lab 2007, 53:1-9

Schernikau E
Spezielle Liquordiagnostik
MTA Dialog, 2(2007), Jahrgang 8:94-97

Plecko T
Massenspektrometrie
MTA Dialog, 2(2007), Jahrgang 8:86-88

Atanasova S, Shipkova M, Svinarov D, Mladenova A, Genova M, Wieland E, Oellerich M, von Ahsen N
Analysis of ITPA phenotype-genotype correlation in the Bulgarian population revealed a novel gene variant in exon 6
Ther Drug Monit, 2007 Feb;29(1):6-10

Schetter V, Wieland E
Effekte der LDL-Apharese - Mehr als nur Cholesterinsenkung?
Dtsch med Wochenschr 2007; 132:575-578

Plecko T
Das neue Gerinnungsmodell
MTA Dialog, 4(2007), Jahrgang 8:278-279

Plecko T, Pfeiffer A
Laborautomation - Potential, Perspektive und IT
MTA Dialog, 6(2007), Jahrgang 8:434-437

Abe M
Hepatitis-C-Virus-DNA
MTA Dialog, 9(2007), Jahrgang 8:686-689

Trautmann M, Lepper PM, Blessing J, Schutz T, Gförer S, Regnath T, Reiter W, Rieger T, Wellinghausen N, Essig A
In-vitro-Empfindlichkeit von Piperacillin-nicht-sensiblen Enterobaktriazeen und Pseudomonas aeruginosa gegenüber Piperacillin/Tazobactam im Vergleich zu Piperacillin/Sulbactam
Chemotherapie Journal 4(2007), Jahrgang 16:123ff

Lethaus B, Luz H, Weingart D
Der Risikopatient in der zahnärztlichen Praxis
Zahnärzteblatt BW 2007, Okt;10:29-37

Plecko T, Pfeiffer A, Wieland E
Laborautomation im Krankenhaus: Systeme, IT, Potentiale und Perspektiven
J Lab Med 2007:31(5):226-235

Asif AR, Armstrong VW, Voland A, Wieland E, Oellerich M, Shipkova M
Proteins identified as targets of the acyl glucuronide metabolite of mycophenolic acid in kidney tissue from mycophenolate mofetil treated rats.
Biochimie 2007;89:393-402

Reinshagen M, Schütz E, Armstrong VW, Beherns C, von Tirpitz C, Stallmach A, Herfahrt H, Stein J, Bias P, Adler G, Shipkova M, Kruis W, Oellerich M, von Ahsen N
6-Thioguanine nucleotide-adapted azathioprine therapy in cronic active crohn disease. Results from a randomized, controlled, open trial.
Clin Chem 2007;53:1306-1314

Shipkova M, Franek G, Wieland E
The use of the EMIT urine benzodiazepine assay (Dade Behring) on the dimension system with serum samples in order to improve the detection of Midazolam
Ther Drug Monit 2007;29:462

Shipkova M, Besenthal I, Franek G, Vogeser M, Wieland E
Comparative analysis of the tacrolimus concentrations determined by the new ACMIA Tacrolimus assay on the Dimension system and by LC-MS/MS, EMIT and MEIA
Ther Drug Monit 2007;29:509-510

Stracke S, Mayer J, Keller F, Zargoum A, Yang L, Henne-Bruns D, Wieland E, Shipkova M
Mycophenolate sodium (EC-MPS) in kidney transplant recipients (KTx): Pharmacokinetics in the early phase of post transplantation
Ther Drug Monit 2007;29:529

Feichtiger H, Wieland E, Armstrong VW, Shipkova M
The acyl glucuronide metabolite of Mycophenolic acid induces tubulin polymerization in vitro
Ther Drug Monit 2007;29:539-540

Shipkova M, Heller T, Petrova DT, Hitt R, Wieland E, Oellerich M, Armstrong VW
A microarray investigation on the effect of the acyl glucuronide of mycophenolic acid (AcMPAG) on the expression of cell proliferation related genes in mononuclear leucocytes
Clin Chem Lab Med 2007;45:A104-A105

Atanasova S, Wieland E, Schlumbohm C, von Ahsen N, Fuchs E, Oellerich M, Armstrong VW
Prenatal dexamethasone exposure enhances the gene expression of antioxidant enzymes in the aortas of marmoset offspring
Clin Chem Lab Med 2007;45:A104-A105

Shipkova M, Schütz E, Haug R, Besenthal I, Fraunberger P, Wieland E
Investigation of the cross reactivity of mycophenolic acid (MPA) glucuronide metabolites in the CEDIAMPA assay
Euromedlab 17th IFCC-FESCC Congress, 03.06.-07.06.2007 Amsterdam
Clin Chem Lab Med 2007;45:406

Plecko T, Wieland E
Installation of a total laboratory automation system:
Effect on laboratory budget, personnel, and TAT
Euromedlab 17th IFCC-FESCC Congress, 03.06.-07.06.2007 Amsterdam
Clin Chem Lab Med 2007;45:202

Abe M, Klett C, Wieland E
Simultaneous quantification and genotyping of Hepatitis C virus RNA by a two-step real-time fluorescence reverse transcriptase-initiated PCR assay on the LightCycler instrument
Euromedlab 17th IFCC-FESCC Congress, 03.06.-07.06.2007 Amsterdam
Clin Chem Lab Med 2007;45:128

2006

Proteins identified as targets of the acyl glucoronide metabolite of mycophenolic acid in kidney tissue from mycophenolate mofetil treated rats
Asif AR, Armstrong VW, Voland A, Wieland E, Oellerich M, Shipkova M
Biochimie 2006, Oct 16 

Measurement of erythrocyte inosine triphosphate pyrophosphohydrolase (ITPA) activity by HPLC and correlation of ITPA genotype-phenotype in a Caucasion population
Shipkova M, Lorenz K, Oellerich M, Wieland E, von Ahsen N
Clin Chem 2006, 52(2):240-7

Marmoset glutathione peroxidases: cDNA sequences, molecular evolution and gene expression
Atanasova S, von Ahsen N, Schlumbohm C, Wieland E, Oellerich M, Armstrong V
J Med Primatol 2006, 35(3):155-64

Arteriosklerose - Hyperlipoproteinämie. Wieland E in:
Ernährungsmedizin, Prävention und Therapie, 3. Aufl., Schauder P, Ollenschläger G (Hrsg.)
Urban & Fischer München, 2006, 968 ff.

Fettstoffwechselstörungen. Wieland E et al. in:
Zukunft sichern: Senkung der Zahl chronisch Kranker, 1. Aufl., Schauder P, Berthold H, Eckel H, Ollenschläger G (Hrsg.)
Deutscher Ärzte-Verlag GmbH, Köln, 2006, 165 ff.

Digoxin and digitoxin cross reactivity in immunoassays after intake of UZARA
Plecko T, Effenberger-Klein A, Ruckenbrod B, Klein F, Thürmann P, Wieland E, Alken RG
DGKL Kongress, 01.10.-04.10.2006 Mannheim

Internally controlled simultaneous real time PCR of the MecA gene and the S. aureus SCCmec-orfX gene junction region for the detection of methicillin-resistant staphylococcus aureus (MRSA) directly from swab specimen on the LightCycler instrument
Abe M, Klett C, Beyer-von Voigt T, Reiter R, Trautmann M, Gille S, Landt O, Wieland E
DGKL Kongress, 01.10.-04.10.2006 Mannheim

Performance of the mycophenolic acid method on the Dade Behring Dimension clinical chemistry system
Goss SPA, Driscoll JA, McClafferty TA, Edwards RL, Chun A, Kilgore D, Shipkova M, Wieland E
AACC Annual Meeting, 23.07.-27-07.2006 Chicago IL, USA

Multicenter evaluation of a new HDL-cholesterol reagent on Roche/Hitachi, COBAS INTEGRA and Olympus analysis systems
Busse Grawitz A, Cole TG, Fresi P, Hoefner D, Leary ET, Lindemans J, Plecko T et al.
AACC Annual Meeting, 23.07.-27-07.2006 Chicago IL, USA

Comparability between automated immunoassays and LC-MS/MS for Tacrolimus determination using routine patient samples
Domke I, Vukovich T, Engelmayer J, Kheradmand M, Luthe H, Shipkova M, Streit F, Oellerich M, Wieland E
AACC Annual Meeting, 23.07.-27-07.2006 Chicago IL, USA

Cyclosporin determination with different immunoassays in four laboratories using routine patient samples from different transplant types: performance of automated immunoassays and comparability to tandem mass spectrometry
Domke I, Shipkova M, Engelmayer J, Kheradmand M, Luthe H, Pou L, Streit F, Vukovich T, Oellerich M, Wieland E
AACC Annual Meeting, 23.07.-27-07.2006 Chicago IL, USA

2005

Mycophenolate mofetil in organ transplantation: focus on metabolism, safety and tolerability
Shipkova M, Armstrong VW, Oellerich M, Wieland E.
Expert Opin Drug Metab Toxicol 2005, 1(3):505-26 

Pharmakokinetics and bioavailability of mycophenolic acid after intravenous administration of mycophenolate Mofetil to heart transplant recipients
Armstrong VW, Tenderich G, Shipkova M, et al.
Ther Drug Monit 2005, 27(3):315-321

Glucuronidation in therapeutic drug monitoring
Shipkova M, Wieland E.
Clin Chim Acta 2005, 358(1-2):2-23

Mycophenolic acid interaction with cyclosporine and tacrolimus in vitro and in vivo: evaluation of additive effects on rat blood lymphocyte function
Barten MJ, Shipkova M, Bartsch P, et al.
Ther Drug Monit 2005, 27(2):123-131

2004

Potential pitfalls of comparative measurements of reticulocytes with flow cytometry and microscopy in prematures and infants.
Wiegand G, Effenberger-Klein A., Weber R, Kosanke W, Niethammer D, Bruchelt G.
Clin Chem. Lab Med 2004, 42(10):1150-1154

Determination of thiopurine methyltransferase activity in isolated human erythrocytes does not reflect putative in vivo enzyme inhibition by sulfasalazine.
Shipkova M, Niedmann PD, Armstrong VW, Oellerich M, Wieland E.
Clin Chem. 2004,50:438-41.

Expression of E-selectin and its transcripts during intestinal ischemia-reperfusion injury in pigs.
Braun F, Hosseini M, Wieland E, Sattler B, Laabs S, Lorf T, Muller AR, Fandrich F, Kremer B, Ringe B.
Transplant Proc. 2004, 36:265-6.

Kinetics and localization of interleukin-2, interleukin-6, heat shock protein 70, and interferon gamma during intestinal-rerfusion injury.
Braun F, Hosseini M, Wieland E, Sattler B, Muller AR, Fandrich F, Kremer B, Ringe B.
Transplant Proc.2004, 36:267-9.

cDNA microarray analysis reveals new candidate genes possibly linked to side effects under mycophenolate mofetil therapy
Shipkova M, Spielbauer B, Gröne HJ, Armstrong VW, Oellerich M, Wieland E.
Transplantation 2004, 78(8):1145-52

Identification of protein targets for mycophenolic acid acyl glucuronide in rat liver and colon tissue
Shipkova M, Beck H, Voland A, Armstrong VW, Gröne HJ, Oellerich M, Wieland E.
Proteomics 2004, 4(9):2728-38
Buchbeiträge

LDL-Aphareseverfahren. Schettler V, Wieland E in:
Dialyseverfahren in Klinik und Praxis, Technik und Klinik, 6. Aufl., Hörl W, Wanner C (Hrsg.)
Georg Thieme Verlag Stuttgart, 2004, 116 ff.

2003

Effect of age and hypoxia/reoxygenation on mRNA expression of antioxidative enzymes in rat liver and kidneys.
Martin R, Fitzl G, Mozet C, Martin H, Welt K, Wieland E.
Exp Gerontol 37, 1481-1487. 

Is There Evidence for Excessive Free Radical Production In Vivo during Ultrasound-Assisted Liposuction?
Herr J, Hofheinz H, Hertl C, Olbrisch RR, Wieland E.
Plast Reconstr Surg 111, 425-429.

No acute impact of haemodialysis treatment on free radical scavenging enzyme gene expression in white blood cells.
Schettler V, Kuhn W, Kleinoeder T, Armstrong VW, Oellerich M, Muller GA, Wieland E.
J Intern Med 253, 201-207.

KAcyl glucuronide drug metabolites: toxicological and analytical implications.
Shipkova M, Armstrong VW, Oellerich M, Wieland E.
The Drug Monit 25, 1-16.

Differences in nucleotide hydrolysis contribute to the differences between erythrocyte 6-thioguanine nucleotide concentrations determined by two widely used methods.
Shipkova M, Armstrong VW, Wieland E, Oellerich M.
Clin Chem 49, 260-268.

No acute impact of lipid apheresis treatment on free radical scavenging enzyme gene expression in white blood cells.
Schettler V, Krontal J, Scheel A, Wieland E.
Eur J Clin Invest 33, 134-140

2017

Shipkova M, Rapp S, Rigo-Bonnin R, Wieland E, Peter A.
Therapeutic Drug Monitoring of everolimus: comparability of concentrations determined by two immunoassays and a LC-MS/MS method.
Ther Drug Monit. 2017 Jan 24. doi: 10.1097/FTD.0000000000000376. [Epub ahead of print]