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Centre for Clinical Pathology, Pharmacy and Hygiene

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Institute of Pathology, with practice for Pathology

Medical Centre Director
Prof. Dr. Alexander Bosse
Medical Director

Telephone +49 (0)711 278-34901
Telefax +49 (0)711 278-34909
a.bosse@klinikum-stuttgart.de

The Institute is responsible for pathological services of the buildings of Stuttgart Hospital, apart from which other hospitals in the region receive diagnostic services. The affiliated ambulatory medical office for pathology processes tissue samples on behalf of resident physicians and hospital outpatient departments. This ensures that the entire morphological diagnosis can be carried out considering each synoptic innovative diagnostic possibilities in pathology. At the Institute of Pathology more than 35,000 tissue samples are examined annually.

Treatment and care priorities

Histological examinations
Cytological examinations
Immunohistochemical tumour differentiation
Sections
Regular clinical-pathological meetings with the hospitals to be served
Neuropathology
Regular weekly participation in the conferences of the certified Intestine, Breast, Pancreas and Prostate cancer centres as well as the certified centre for Gynaecological Cancers (total approx. 150 p.a.) of Stuttgart Hospital
Cooperating partners in the Prostate and Thyroid centre of the Diaconal Hospital

Special offers and facilities

Molecular pathology diagnostics for pathogen detection using PCR and in situ hybridization (e.g., herpes virus, toxoplasmosis, Pneumocystis carinii, tuberculosis etc.)
Fluorescent in situ hybridization (FISH) for tumour diagnostics and in particular oncogene determination in breast and colon cancers
PCR testing for Borrelia detection, among other things through ticks
Implementation of resistance testing of Helicobacter bacteria in fixed tissue samples

Exceptional procedures in Diagnosis and Therapy

Forensic DNA analysis (e.g., parentage testing, identification and traces analysis)
Determination of KRAS mutation status (as a predictive biomarker in the anti-EGFR therapy for colorectal cancer)

Scientific activities

PhD project on comparison of methods for the determination of KRAS mutation status

Quality assurance (selection)

Regular participation in proficiency testing for KRAS mutation screening
Regular participation in proficiency testing for trace analysis
Regular participation in proficiency testing for parentage verification
Accreditation of the forensic division according to ISO 17025

Selected services (case number)

2008	2009	2010
3,614	4,031	3,705	Immunohistochemical examinations
696	720	732	Molecular pathology examinations
93	89	100	Sections
35	41	73	Forensic DNA analysis

Institute of Pathology,
with practice for Pathology

Klinikum Stuttgart – Katharinenhospital
Kriegsbergstrasse 60
70174 Stuttgart
Germany

Telephone +49 (0)711 278-34901
Telefax +49 (0)711 278-34909
a.bosse@klinikum-stuttgart.de

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